AlphaFold 3 alternatives in 2026: 24 tools like AlphaFold 3

Closest: Science & Biology Models

Chai-1

Chai Discovery's open-weights biomolecular structure prediction model

Curated

0 use thisCompare with AlphaFold 3
ESM

Biohub's protein language and structure prediction model family

Curated

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ether0

Open 24B reasoning model post-trained for chemistry and molecule design

Curated

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Glyph

Open models that turn chemical structure images into machine-readable molecules

Curated

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ZUNA

Open EEG foundation model for denoising and reconstructing brain signals

Curated

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More in Foundation Models

ChatGPT

OpenAI's flagship family, unifying the former o-series reasoners

CuratedAndroidiOSMacWebWindows

3 use thisCompare with AlphaFold 3
Claude

Anthropic's model family in Haiku, Sonnet, Opus, and Fable tiers

CuratedAndroidiOSMacWebWindows

2 use thisCompare with AlphaFold 3
Gemini

Google DeepMind's multimodal family with built-in thinking modes

CuratedAndroidiOSMacWebWindows

1 use thisCompare with AlphaFold 3
Grok

xAI's frontier model family with real-time X data access

Curated

1 use thisCompare with AlphaFold 3
Mistral

Mistral AI's model family, from Small and Medium up to Large

Curated

1 use thisCompare with AlphaFold 3
Amazon Nova

Amazon's multimodal model family served through Bedrock

Curated

0 use thisCompare with AlphaFold 3
Ampersand

Collaborator model for helping groups reach shared goals, via API

Curated

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Beam

Reflection AI's 501B open-weight model for coding and agent work

Curated

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Command

Cohere's RAG and tool-use optimized enterprise model family

Curated

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DeepSeek-V

DeepSeek's MIT-licensed MoE family with hybrid reasoning (V4, R1)

Curated

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Falcon

TII's open-weights language model family

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Gemma

Google's lightweight open-weights model family

Curated

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GLM

Z.ai's open-weights MoE family for agentic coding and reasoning

CuratedWeb

0 use thisCompare with AlphaFold 3
gpt-oss

OpenAI's Apache 2.0 open-weights reasoning models (20B and 120B)

CuratedWeb

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Granite

IBM's Apache 2.0 enterprise model family for language and code

Curated

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Inkling

Open-weight multimodal MoE model from Thinking Machines Lab

Curated

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Jamba

AI21's hybrid Mamba-Transformer open models for long context

Curated

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Kimi

Moonshot AI's trillion-scale open-weights MoE family for agents

Curated

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LFM

Liquid AI's open-weights models built to run on phones, laptops and cars

Curated

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Questions

What are the closest alternatives to AlphaFold 3?

Chai-1, ESM and ether0 sit on the same sub-line as AlphaFold 3 (Science & Biology Models) on AI Landscape, with 2 more.

How are these alternatives chosen?

They are the other products on the Foundation Models stop of the map: curated products first, the ones on AlphaFold 3's sub-line before the rest, then by name until members have marked enough of them.