ESM alternatives

Closest: Science & Biology Models

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  AlphaFold 3

  Google DeepMind's biomolecular structure prediction model, weights on request

  Curated
  0 use thisCompare with ESM
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  Chai-1

  Chai Discovery's open-weights biomolecular structure prediction model

  Curated
  0 use thisCompare with ESM
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  ether0

  Open 24B reasoning model post-trained for chemistry and molecule design

  Curated
  0 use thisCompare with ESM
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  Glyph

  Open models that turn chemical structure images into machine-readable molecules

  Curated
  0 use thisCompare with ESM
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  ZUNA

  Open EEG foundation model for denoising and reconstructing brain signals

  Curated
  0 use thisCompare with ESM

More in Foundation Models

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  ChatGPT

  OpenAI's flagship family, unifying the former o-series reasoners

  CuratedAndroidiOSMacWebWindows
  3 use thisCompare with ESM
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  Claude

  Anthropic's model family in Haiku, Sonnet, Opus, and Fable tiers

  CuratedAndroidiOSMacWebWindows
  2 use thisCompare with ESM
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  Gemini

  Google DeepMind's multimodal family with built-in thinking modes

  CuratedAndroidiOSMacWebWindows
  1 use thisCompare with ESM
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  Grok

  xAI's frontier model family with real-time X data access

  Curated
  1 use thisCompare with ESM
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  Mistral

  Mistral AI's model family, from Small and Medium up to Large

  Curated
  1 use thisCompare with ESM
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  Amazon Nova

  Amazon's multimodal model family served through Bedrock

  Curated
  0 use thisCompare with ESM
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  Ampersand

  Collaborator model for helping groups reach shared goals, via API

  Curated
  0 use thisCompare with ESM
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  Beam

  Reflection AI's 501B open-weight model for coding and agent work

  Curated
  0 use thisCompare with ESM
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  Command

  Cohere's RAG and tool-use optimized enterprise model family

  Curated
  0 use thisCompare with ESM
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  DeepSeek-V

  DeepSeek's MIT-licensed MoE family with hybrid reasoning (V4, R1)

  Curated
  0 use thisCompare with ESM
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  Falcon

  TII's open-weights language model family

  Curated
  0 use thisCompare with ESM
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  Gemma

  Google's lightweight open-weights model family

  Curated
  0 use thisCompare with ESM
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  GLM

  Z.ai's open-weights MoE family for agentic coding and reasoning

  CuratedWeb
  0 use thisCompare with ESM
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  gpt-oss

  OpenAI's Apache 2.0 open-weights reasoning models (20B and 120B)

  CuratedWeb
  0 use thisCompare with ESM
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  Granite

  IBM's Apache 2.0 enterprise model family for language and code

  Curated
  0 use thisCompare with ESM
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  Inkling

  Open-weight multimodal MoE model from Thinking Machines Lab

  Curated
  0 use thisCompare with ESM
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  Jamba

  AI21's hybrid Mamba-Transformer open models for long context

  Curated
  0 use thisCompare with ESM
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  Kimi

  Moonshot AI's trillion-scale open-weights MoE family for agents

  Curated
  0 use thisCompare with ESM
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  LFM

  Liquid AI's open-weights models built to run on phones, laptops and cars

  Curated
  0 use thisCompare with ESM

Questions